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首页> 外国专利> DIAGNOSTIC PREDICTION OF RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS

DIAGNOSTIC PREDICTION OF RHEUMATOID ARTHRITIS AND SYSTEMIC LUPUS ERYTHEMATOSUS

机译：类风湿关节炎和系统性红斑狼疮的诊断预测

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The present invention pertains to a diagnostic assay for the diagnosis of an autoimmune disease. The present invention provides an improved diagnostic assay for the diagnosis of an autoimmune disease, particularly rheumatoid arthritis (RA) and Systemic Lupus Erythematosus (SLE). In particular the invention pertains to a method of determining in a sample of a subject the presence of two or more antibodies comprising the step of determining whether an antibody is present in a sample that specifically recognizes a hnRNP-DL polypeptide or a fragment thereof or a splice variant thereof and the further step of determining whether at least one further antibody is present in the sample that specifically recognizes a at least one other hnRNP polypeptide which is not sequence homologue to said hnRNP-DL polypeptide or fragments thereof or splice variants thereof, and/or said CCP peptide and/or a polypeptide comprising at least the Fc-part of IgG, respectively. The invention also relates to polypeptides, protein sets and antibodies that may be used in such methods and assays and for therapeutic use in RA and SLE patients.
机译：本发明涉及用于诊断自身免疫疾病的诊断测定法。本发明提供了用于诊断自身免疫疾病，特别是类风湿性关节炎（RA）和系统性红斑狼疮（SLE）的改进的诊断测定法。特别地，本发明涉及确定受试者的样品中两种或更多种抗体的存在的方法，该方法包括确定样品中是否存在特异性识别hnRNP-DL多肽或其片段或抗体的抗体。确定其剪接变体的进一步步骤，以及确定样品中是否还存在至少一种抗体，该抗体可特异性识别至少一个与所述hnRNP-DL多肽或其片段或剪接变体同源的序列的至少一个其他hnRNP多肽，以及/或所述CCP肽和/或分别包含至少IgG的Fc部分的多肽。本发明还涉及可用于此类方法和测定中并用于RA和SLE患者的治疗用途的多肽，蛋白质组和抗体。

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