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Nitrated cardiac troponin I as a biomarker of cardiac ischemia

机译:硝化的心肌肌钙蛋白I作为心肌缺血的生物标志物

摘要

The present invention relates to the identification of a novel biomarker for cardiac ischemia: nitrated cardiac troponin I. The present invention also provides methods for the identification and use of a nitrated cardiac troponin as a biomarker for the diagnosis, prognosis and treatment management of myocardial ischemia, with and without necrosis of heart muscle.;Diagnosis and prognosis is conducted by determining the amount of nitrated cardiac troponin I in serum samples of subjects and the ratio of nitrated cardiac troponin I to non-nitrated cardiac troponin I in serum samples of subjects. This biomarker can be detected by immunoassay techniques and tandem mass spectrometry. The present invention further relates to peptides, antibodies, compositions, methods, techniques, tests and kits for the identification and quantification of nitrated cardiac troponin I in samples of subjects.
机译:本发明涉及用于心肌缺血的新型生物标志物的鉴定:硝化的心肌肌钙蛋白I。本发明还提供了鉴定和使用硝化的心肌肌钙蛋白作为用于心肌缺血的诊断,预后和治疗管理的生物标志物的方法。诊断和预后是通过确定受试者血清样品中硝化的心肌肌钙蛋白I的量以及受试者血清样品中硝化的心肌肌钙蛋白I与未硝化的心肌肌钙蛋白I的比率来进行的。可以通过免疫测定技术和串联质谱检测该生物标记。本发明进一步涉及用于鉴定和定量对象样品中硝化的心脏肌钙蛋白I的肽,抗体,组合物,方法,技术,测试和试剂盒。

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