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首页> 外国专利> METHOD FOR PRODUCING EXTRACELLULAR MATRIX MEMBRANE DERIVED FROM BIOCOMPATIBLE PORCINE CARTILAGE CAPABLE OF REGULATING IN VIVO DECOMPOSITION RATE AND PHYSICAL PROPERTIES, AND COMPOSITION FOR PREVENTING ADHESION CONTAINING EXTRACELLULAR MATRIX DERIVED FROM PORCINE CARTILAGE AS ACTIVE INGREDIENT

METHOD FOR PRODUCING EXTRACELLULAR MATRIX MEMBRANE DERIVED FROM BIOCOMPATIBLE PORCINE CARTILAGE CAPABLE OF REGULATING IN VIVO DECOMPOSITION RATE AND PHYSICAL PROPERTIES, AND COMPOSITION FOR PREVENTING ADHESION CONTAINING EXTRACELLULAR MATRIX DERIVED FROM PORCINE CARTILAGE AS ACTIVE INGREDIENT

机译：制备具有可调节体内分解速率和物理性质的可生物相容的猪软骨的细胞外基质膜的方法，以及用于预防由活性的猪软骨衍生的包含细胞外基质的粘附的组合物

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摘要

The present invention relates to a method for preparing a biocompatible porcine cartilage-derived extracellular matrix membrane capable of adjusting an in-vovo degradation rate and a mechanical property, and a composition containing the porcine cartilage-derived extracellular matrix as an active ingredient, for preventing adhesion between tissues and/or organs. Despite its high biocompatibility as a natural material, cartilage tissue extracellular matrix has a short decomposition period and its mechanical property is weak, thereby restricting the application. Accordingly, a method of enhancing the mechanical property through physical or chemical treatment and radiation treatment has been developed. In the present invention, biomaterials of various formulations were produced by treating the porcine cartilage-derived extracellular matrix with physiochemical methods. In addition, although was carried out, a characteristic that the above cartilage-specific function was maintained despite the treatment of the physico-chemical treatment was checked. Furthermore, it may also be used as an adhesion inhibitor with excellent in-vivo stability and anti-adhesion effect by using the porcine cartilage-derived extracellular matrix material.
机译：本发明涉及一种能够调节体内降解速率和机械性能的生物相容性猪软骨来源的细胞外基质膜的制备方法，以及一种以猪软骨来源的细胞外基质为有效成分的组合物，用于预防组织和/或器官之间的粘附。尽管其作为天然材料具有高的生物相容性，但软骨组织细胞外基质具有短的分解周期并且其机械性能弱，从而限制了其应用。因此，已经开发了通过物理或化学处理和辐射处理来增强机械性能的方法。在本发明中，通过用理化方法处理猪软骨来源的细胞外基质来制备各种制剂的生物材料。此外，尽管进行了该检查，但是检查了尽管进行了物理化学处理仍保持了上述软骨特异性功能的特征。此外，通过使用猪软骨来源的细胞外基质材料，也可以用作具有优异的体内稳定性和抗粘附作用的粘附抑制剂。

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