首页> 外国专利> SUPERPARAMAGNETIC PARTICLE IMAGING AND ITS APPLICATIONS IN QUANTITATIVE MULTIPLEX STATIONARY PHASE DIAGNOSTIC ASSAYS

SUPERPARAMAGNETIC PARTICLE IMAGING AND ITS APPLICATIONS IN QUANTITATIVE MULTIPLEX STATIONARY PHASE DIAGNOSTIC ASSAYS

机译:超顺磁粒子成像及其在定量多相定相诊断分析中的应用

摘要

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.
机译:基于超顺磁性纳米粒子的分析方法,包括提供在样品基质中具有分析物的样品,提供具有分析区域的护理点芯片,其中每个分析区域是具有至少一个或多个部分的固定相,并用超顺磁性标记每个分析物纳米颗粒并将标记的分析物固定在固定相中,提供了一种分析设备,该设备具有用于在体外激发超顺磁性纳米颗粒的装置以及用于感测,接收和传输被激发的超顺磁性纳米颗粒的响应的装置,并将芯片放置在分析装置中,在体外激发超顺磁性纳米粒子,感测,接收和传输超顺磁性纳米粒子的响应,并分析响应和确定分析物的特征,其中超顺磁性纳米粒子的响应包括谐波。本发明还提供了在分析方法中使用的混合点护理芯片和分析仪。

著录项

  • 公开/公告号US2019317167A1

    专利类型

  • 公开/公告日2019-10-17

    原文格式PDF

  • 申请/专利权人 MARS SCIENCES LIMITED;

    申请/专利号US201916379748

  • 发明设计人 RONALD T. LABORDE;YU GE;KEVIN N. WALDA;

    申请日2019-04-09

  • 分类号G01R33/56;G01R33/07;A61K49/18;G01N33/58;G01N33/558;

  • 国家 US

  • 入库时间 2022-08-21 12:12:50

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