首页> 外国专利> Protein matter is replaced in typesetting, replace replacement gene, carrier, transformant, pyruvic acid contains in the method for complex-type sugar chain, and pyruvic acid contains the manufacturing method of complex-type sugar chain modification protein, and complex-type sugar chain and pyruvic acid of the fibrous nodules bottle containing acid contain complex-type sugar chain modification.

Protein matter is replaced in typesetting, replace replacement gene, carrier, transformant, pyruvic acid contains in the method for complex-type sugar chain, and pyruvic acid contains the manufacturing method of complex-type sugar chain modification protein, and complex-type sugar chain and pyruvic acid of the fibrous nodules bottle containing acid contain complex-type sugar chain modification.

机译：排版中的蛋白质物质被替换，替换替换基因，载体，转化体，丙酮酸包含在复杂类型糖链的方法中，丙酮酸包含复杂类型糖链修饰蛋白的制造方法和复杂类型糖链的制造方法纤维状结节瓶中含有丙酮酸的丙酮酸含有复杂类型的糖链修饰。

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摘要

Provided are: a sugar chain having a complex sugar chain structure that is scarcely affected by decomposing enzymes in the blood; a glycoprotein having the sugar chain; a method for producing the sugar chain and a method for producing the glycoprotein; and a recombinant protein, a recombinant gene, a recombinant vector and a transformant that are to be used in the aforesaid production methods. The recombinant protein according to the present invention is characterized by being defined by (a) or (b): (a) a protein comprising an amino acid sequence represented by any of SEQ ID NOs: 1 to 13; and (b) a protein comprising an amino acid sequence that is derived from an amino acid sequence represented by any of SEQ ID NOs: 1 to 13 by deletion, insertion, substitution or addition of one to several amino acids at a position other than amino acid position 168, and having a pyruvic acid transfer activity specific to galactose.

机译：提供：具有复杂糖链结构的糖链，该糖链几乎不受血液中酶分解的影响;具有糖链的糖蛋白;糖链的制造方法和糖蛋白的制造方法;上述生产方法中使用的重组蛋白，重组基因，重组载体和转化体。根据本发明的重组蛋白的特征在于由（a）或（b）定义：（a）一种蛋白质，其包含由SEQ ID NO：1至13中的任一个表示的氨基酸序列; （b）一种蛋白质，其包含通过在氨基酸以外的位置缺失，插入，取代或添加一个至几个氨基酸而衍生自SEQ ID NO：1至13中任一个的氨基酸序列的氨基酸序列。酸位168，具有对半乳糖特异的丙酮酸转移活性。

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公开/公告号JP6472085B2

专利类型
公开/公告日2019-02-20

原文格式PDF
申请/专利权人国立大学法人九州大学;
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申请/专利号JP20150534183
发明设计人竹川薫;
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申请日2014-08-22
分类号C12N9/10;C12N15/54;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P19/28;C08B37;
国家 JP
入库时间 2022-08-21 12:18:10

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