首页> 外国专利> 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions containing the same (1, 3, 4-Oxadiazole Sulfamide Derivatives Compounds as Histone Deacetylase 6 Inhibitor , And the Pharmaceutical Composition Composing the same)

1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions containing the same (1, 3, 4-Oxadiazole Sulfamide Derivatives Compounds as Histone Deacetylase 6 Inhibitor , And the Pharmaceutical Composition Composing the same)

机译：1,3,4-恶二唑磺酰胺衍生物化合物作为组蛋白脱乙酰基酶6抑制剂和包含该化合物的药物组合物（1、3,4-4-恶二唑磺酰胺衍生物化合物作为组蛋白脱乙酰基酶6抑制剂和组成相同的药物组合物）

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摘要

The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.

机译：本发明涉及具有组蛋白脱乙酰基酶6（HDAC6）抑制活性的新型化合物，其立体异构体或其药学上可接受的盐，其在制备治疗药物中的用途，包含该化合物的药物组合物，使用该组合物治疗疾病的方法，以及制备新化合物的方法。根据本发明的新型化合物，其立体异构体或其药学上可接受的盐具有组蛋白脱乙酰基酶（HDAC）抑制活性，并且对于预防或治疗HDAC6介导的疾病，包括传染病是有效的。肿瘤内分泌，营养和代谢性疾病;精神和行为障碍;神经系统疾病;眼和附件疾病;心血管疾病;呼吸疾病;消化系统疾病;皮肤和皮下组织疾病;肌肉骨骼系统疾病和结缔组织疾病;或先天性畸形，变形和染色体异常。

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公开/公告号JP6538266B2

专利类型
公开/公告日2019-07-03

原文格式PDF
申请/专利权人チョンクンダンファーマシューティカルコーポレーション;
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申请/专利号JP20180504096
发明设计人リー;ジェクワン;ハン;ヨンフェ;キム;ユンテ;ミン;ジェキ;ベ;ミソン;キム;ドフン;ジン;ソクミン;キュン;ジャンビン;
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申请日2016-07-27
分类号C07D271/10;A61P43;A61P31;A61P35;A61P3;A61P5;A61P25;A61P27/02;A61P11;A61P9;A61P1;A61P17;A61P19;A61P21;A61K31/5377;A61K31/496;C07D413/12;C07D413/04;C07D413/14;C07D471/10;
国家 JP
入库时间 2022-08-21 12:20:04

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