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METHOD FOR BUILDING MODEL OF ANIMAL SUFFERING FROM NON-HUMAN MAMMAL OBESITY OR RELATED DISEASE AND USE THEREOF
METHOD FOR BUILDING MODEL OF ANIMAL SUFFERING FROM NON-HUMAN MAMMAL OBESITY OR RELATED DISEASE AND USE THEREOF
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机译:建立非人类哺乳动物肥胖或相关疾病动物模型的方法及其应用
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摘要
A method for preparing a non-human mammalian animal model suffering from obesity or a related disease, comprising the following steps: (a) providing a non-human mammalian cell, and inactivating Glce gene in the cell, thereby obtaining a non-human mammalian cell with an inactivated Glce gene; and (b) using the cell with the inactivated Glce gene obtained in step (a) to prepare and obtain an animal model suffering from Glce gene-inactivated obesity or related diseases. The animal model is an effective animal model suffering from obesity or a related disease, and is useful for researching diseases such as obesity, hyperlipidemia, hypertension, and diabetes, and is useful for in experiments for screening and testing specific medicines.
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