Provided herein are encoded split pool libraries useful,inter alia,for forming highly diverse and dense arrays for screening and detection of a variety of molecules. In particular the application discloses a method comprising:(i) providing a solid support comprising a plurality of wells;(ii) attaching a plurality of microparticles to said plurality of wells to form an ordered array of a plurality of immobilized microparticles, wherein each of said plurality of immobilized microparticles is further covalently attached to:(a) a ligand domain through a first linker; and(b) a nucleic acid domain through a second linker;wherein said second linker is cleavable and said first linker is not cleavable under a condition that said second linker is cleavable;(iii) performing a decoding procedure on the nucleic acid domain, thereby identifying the composition of the ligand domain and its location on said solid support.
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