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NEGATIVELY CHARGED SELF-ASSEMBLING SUPPORTED LIPID BILAYER ON MESOPOROUS SILICA NANOPARTICLES, METHOD OF SYNTHESIS AND USE AS A NANOVECTOR
NEGATIVELY CHARGED SELF-ASSEMBLING SUPPORTED LIPID BILAYER ON MESOPOROUS SILICA NANOPARTICLES, METHOD OF SYNTHESIS AND USE AS A NANOVECTOR
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机译:介孔二氧化硅纳米粒子上带负电荷的自组装脂质双分子层,合成方法及用作纳米晶
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摘要
A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.
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