首页> 外国专利> LENTIVIRAL VECTORS FOR REGULATED EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR MOLECULE

LENTIVIRAL VECTORS FOR REGULATED EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR MOLECULE

机译:调控嵌合抗原受体分子表达的细小病毒载体

摘要

The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors. The invention in particular relates to an isolated cell comprising a nucleic acid molecule, a nucleic acid vector or a lentiviral vector encoding a CAR and a method for expressing the CAR in a cell.
机译:本发明涉及慢病毒载体中嵌合抗原受体(CAR)的调节表达。 CAR包含与钩相互作用的钩结合结构域,所述钩结合结构域优选由相同的慢病毒载体编码,这阻止了CAR的正确加工和释放至细胞膜。本发明包括载体,制备载体的方法和使用它们的方法,包括药物用途。该载体可用于施用于人以诱导免疫反应以及治疗癌症和肿瘤。本发明尤其涉及包含编码CAR的核酸分子,核酸载体或慢病毒载体的分离的细胞,以及在细胞中表达CAR的方法。

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