Modification of T lymphocytes with lentiviral vectors for expression of anti-CD19 chimeric antigen receptor (CAR)

机译：用慢病毒载体修饰T淋巴细胞以表达抗CD19嵌合抗原受体（CAR）

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Our CAR-T cells specifically detect B cells and lead to cell death within 24 hours of co-cultivation.

机译：我们的CAR-T细胞可特异性检测B细胞并在共培养24小时内导致细胞死亡。

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《Scale-up and manufacturing of cell-based therapies V》|2017年|128-132|共5页
会议地点 San Diego(US)
作者
Virginia Picanco-Castro; Pablo Moco; Daianne MC Fantacini; Marcela CC Freitas; Dimas T. Covas;
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Fundacao Hemocentro de Ribeirao Preto;

Fundacao Hemocentro de Ribeirao Preto;

Fundacao Hemocentro de Ribeirao Preto;

Fundacao Hemocentro de Ribeirao Preto;

Fundacao Hemocentro de Ribeirao Preto;

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正文语种 eng
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专利

1. Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes. [J] . Peng Peter D, Yang Shicheng, Hsu Cary, Human gene therapy . 2009,第6期

机译：慢病毒载体设计，可在外周血淋巴细胞和肿瘤浸润淋巴细胞的转导中优化T细胞受体基因的表达。
2. Off-the-Shelf Natural Killer Cells with Multi-Functional Engineering Using a Novel Anti-CD19 Chimeric Antigen Receptor Combined with Stabilized CD16 and IL15 Expression to Enhance Directed Anti-Tumor Activity [J] . Kaufman Dan S., Bjordahl Ryan, Zhu Huang, Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：使用新型抗CD19嵌合抗原受体结合稳定的CD16和IL15表达，具有多功能工程的现成的自然杀伤细胞，以增强定向的抗肿瘤活性
3. Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells [J] . Daisuke Morita, Nobuhiro Nishio, Shoji Saito, Molecular Therapy - Methods & Clinical Development . 2018,第3期

机译：增强杀菌转座工程工程T细胞抗CD19嵌合抗原受体的表达
4. Modification of T lymphocytes with lentiviral vectors for expression of anti-CD19 chimeric antigen receptor (CAR) [C] . Virginia Picanco-Castro, Pablo Moco, Daianne MC Fantacini, Conference on scale-up and manufacturing of cell-based therapies V . 2017

机译：用慢病毒载体进行T淋巴细胞的改性抗CD19嵌合抗原受体（汽车）的表达
5. Generation of chimeric antigen receptor modified human T lymphocytes for the potent and dual-antigen selective eradication of human cancers in mice. [D] . Kloss, Christopher Carl. 2013

机译：嵌合抗原受体修饰的人T淋巴细胞的产生，可有效和消灭小鼠中的人类癌症。
6. Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes [O] . Stephanie Jones, Peter D. Peng, Shicheng Yang, -1

机译：在外周血淋巴细胞和肿瘤浸润淋巴细胞转导中最佳T细胞受体基因表达的慢病毒载体设计
7. Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes [O] . Jones, Stephanie, Peng, Peter D., Yang, Shicheng, 2009

机译：在外周血淋巴细胞和肿瘤浸润淋巴细胞转导中最佳T细胞受体基因表达的慢病毒载体设计

Modification of T lymphocytes with lentiviral vectors for expression of anti-CD19 chimeric antigen receptor (CAR)

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