首页> 外国专利> GENE TRANSFER INTO AIRWAY EPITHELIAL STEM CELL BY USING SIMIAN LENTIVIRAL VECTOR PSEUDOTYPED WITH SENDAI RNA VIRUS SPIKE PROTEIN

GENE TRANSFER INTO AIRWAY EPITHELIAL STEM CELL BY USING SIMIAN LENTIVIRAL VECTOR PSEUDOTYPED WITH SENDAI RNA VIRUS SPIKE PROTEIN

机译：通过使用仙台RNA病毒样蛋白的猿猴细小病毒伪装基因将基因转移到气道上皮干细胞中

页面导航

摘要
著录项
相似文献

摘要

The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.

机译：本发明人使用F和HN假型的猿猴免疫缺陷病毒载体成功地将基因引入了气道上皮组织的干细胞，所述载体是仙台病毒的包膜糖蛋白。使用本发明的载体将基因转移到气道上皮组织干细胞中对于遗传性呼吸道疾病如囊性纤维化的基因治疗是有用的。此外，可以选择呼吸器官例如肺作为生产组织，以提供由于遗传疾病而缺乏的蛋白质。

著录项

公开/公告号EP2993235B1

专利类型
公开/公告日2019-02-13

原文格式PDF
申请/专利权人 ID PHARMA CO. LTD.;
展开▼

申请/专利号EP20150190286
发明设计人 MITOMO KATSUYUKI;INOUE MAKOTO;IWASAKI HITOSHI;HASEGAWA MAMORU;ALTON ERIC W.;GRIESENBACH UTA;
展开▼

申请日2006-10-27
分类号C12N15/867;A61K35/76;A61K38;A61K48;A61P11;C12N5/10;A61K9;C07K14/47;C12N5/071;C12N15/86;C12N7;A61K38/16;A61K38/17;
国家 EP
入库时间 2022-08-21 12:29:26

相似文献

专利
外文文献
中文文献