首页> 外国专利> ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE TYPE KLEBSIELLA PNEUMONIAE PRODUCING METAL-Β-LACTAMASE

ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE TYPE KLEBSIELLA PNEUMONIAE PRODUCING METAL-Β-LACTAMASE

机译:产金属-β-内酰胺酶的肺炎克雷伯菌肺炎克雷伯氏菌抗卡本革兰氏阴性细菌的抗菌组合

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to clinical microbiology, discloses an antimicrobial combination of the combined use of carbapenems and bisphosphonates with respect to carbapenem-resistant Gram-negative bacteria of the Klebsiella pneumoniae type ATCC 70603, producing metal-β-lactamase (MβL). Antimicrobial combinations are characterized by a weight ratio of components, namely to a combination of imipenem/clodronic acid, meropenem/clodronic acid, imipenem/etidronic acid, meropenem/etidronic acid are used in the ratios of 1:1,875, 1:15,000, 1:50,000, 1:50,000 respectively.;EFFECT: proposed technical solution allows modeling production of strains of Gram-negative microorganisms with different levels of resistance to carbapenems and to evaluate inhibition efficiency of MβL and can be used to overcome the resistance of Gram-negative bacteria of the Klebsiella pneumoniae species producing MβL, to the carbapenems.;1 cl, 5 tbl
机译:技术领域本发明涉及医学,即涉及临床微生物学,公开了碳青霉烯类和双膦酸酯类联合使用对肺炎克雷伯菌肺炎克雷伯氏菌ATCC 70603型革兰氏阴性细菌的抗微生物组合,可产生金属- β-内酰胺酶(MβL)。抗菌剂组合的特征在于组分的重量比,即以1:1,875、1:15,000、1的比例使用亚胺培南/氯膦酸,美洛培南/氯膦酸,亚胺培南/乙二膦酸,美罗培南/甲乙膦酸的组合效果:分别为:50,000、1:50,000 。;效果:建议的技术解决方案可对具有不同碳青霉烯抗性水平的革兰氏阴性微生物菌株进行建模生产,并评估MβL的抑制效率,可用于克服革兰氏阴性菌的抗性碳青霉烯类产生MβL的肺炎克雷伯菌的细菌; 1 cl,5 tbl

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