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ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE TYPE KLEBSIELLA PNEUMONIAE PRODUCING METAL-Β-LACTAMASE
ANTIMICROBIAL COMBINATION FOR CARBAPENEM-RESISTANT GRAM-NEGATIVE BACTERIA OF THE TYPE KLEBSIELLA PNEUMONIAE PRODUCING METAL-Β-LACTAMASE
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机译:产金属-β-内酰胺酶的肺炎克雷伯菌肺炎克雷伯氏菌抗卡本革兰氏阴性细菌的抗菌组合
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摘要
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to clinical microbiology, discloses an antimicrobial combination of the combined use of carbapenems and bisphosphonates with respect to carbapenem-resistant Gram-negative bacteria of the Klebsiella pneumoniae type ATCC 70603, producing metal-β-lactamase (MβL). Antimicrobial combinations are characterized by a weight ratio of components, namely to a combination of imipenem/clodronic acid, meropenem/clodronic acid, imipenem/etidronic acid, meropenem/etidronic acid are used in the ratios of 1:1,875, 1:15,000, 1:50,000, 1:50,000 respectively.EFFECT: proposed technical solution allows modeling production of strains of Gram-negative microorganisms with different levels of resistance to carbapenems and to evaluate inhibition efficiency of MβL and can be used to overcome the resistance of Gram-negative bacteria of the Klebsiella pneumoniae species producing MβL, to the carbapenems.1 cl, 5 tbl
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