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DSCR1-4 2 2 A method for screening a therapeutic agent for type 2 diabetes using DSCR1-4 and a composition for diagnosing type 2 diabetes or predicting prognosis
DSCR1-4 2 2 A method for screening a therapeutic agent for type 2 diabetes using DSCR1-4 and a composition for diagnosing type 2 diabetes or predicting prognosis
The present invention relates to a method for screening a therapeutic agent for type 2 diabetes reducing the binding degree between the down syndrome critical region 1-4 (DSCR1-4) gene and Forkhead box protein O1 (FoxO1), a composition for diagnosis and prognosis of type 2 diabetes, an information providing method for diagnosis and prognosis of type 2 diabetes, and a pharmaceutical composition for prevention or treatment of type 2 diabetes. An increase in the expression level of mRNA and DSCR1-4 genes in the liver cells and liver tissues of mice with induced obesity and diabetes is confirmed. The involvement of the DSCR1-4 genes in regulation of glycogenesis in the liver cells is confirmed in experiments. Accordingly, DSCR1-4 genes are confirmed to be a critical factor with respect to treatment targets of the type 2 diabetes and be useful as a gene marker for treatment of the type 2 diabetes. The DSCR1-4 genes can be variously utilized for pharmaceutical development and screening of the therapeutic agent for type 2 diabetes suppressing expression and activities of genes.
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