首页> 外国专利> METHOD FOR PRODUCING ANIMAL MODEL HAVING COLON POLYP OR COLORECTAL CANCER BY USING INTESTINAL FLORA

METHOD FOR PRODUCING ANIMAL MODEL HAVING COLON POLYP OR COLORECTAL CANCER BY USING INTESTINAL FLORA

机译:利用肠道菌群生产具有结肠息肉或结肠直肠癌的动物模型的方法

摘要

The present invention relates to a method for producing an animal model having a colon polyp or colorectal cancer by using intestinal flora. An animal model, which exhibits a significantly higher colon polyp occurrence efficiency than a conventional animal model having a colon polyp, has been identified by using an Enterotoxigenic Bacteroides fragilis (ETBF) strain, which is human intestinal flora, and a novel mouse model for research on the mechanism of colorectal diseases caused by an ETBF strain has been developed.
机译:本发明涉及通过使用肠道菌群来产生具有结肠息肉或结肠直肠癌的动物模型的方法。通过使用肠毒素的脆弱肠杆菌(ETBF)菌株,鉴定出比具有结肠息肉的常规动物模型具有明显更高的结肠息肉发生效率的动物模型,并开发了一种新型小鼠模型,用于研究由ETBF菌株引起的大肠疾病的机理。

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