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首页> 外国专利> METHODS OF PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM CMS3 COLORECTAL CANCER

METHODS OF PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM CMS3 COLORECTAL CANCER

机译：预测CMS3大肠癌患者生存时间的方法

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摘要

The present invention relates to methods of predicting the survival time of patients suffering from CMS3 colorectal cancer. The inventors performed bivariate Cox models for analyzing the impact of stimulatory/Inhibitory immune checkpoint (ICK) expression on the survival of patients suffering from colorectal cancers (CMS1, CMS2, CMS3, CMS4, and MSI) in 2 cohorts (CIT and TCGA) or when the corhorts are combined. The inventors demonstrated that the expression of stimulatory ICK metagene was associated with good prognosis in CMS3. Thus, the present invention relates to a method of predicting the survival time of a patient suffering from a CMS3 colorectal cancer comprising i) determining the expression level of at least one immune stimulatory checkpoint molecule in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is higher than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is lower than the predetermined reference value.
机译：本发明涉及预测患有CMS3大肠癌的患者的存活时间的方法。发明人进行了双变量Cox模型分析了两个队列（CIT和TCGA）中刺激/抑制性免疫检查点（ICK）表达对大肠癌（CMS1，CMS2，CMS3，CMS4和MSI）患者生存的影响，或者当这些人合在一起时。发明人证明了刺激性ICK基因的表达与CMS3的良好预后相关。因此，本发明涉及预测患有CMS3大肠癌的患者的生存时间的方法，该方法包括：i）确定从该患者获得的肿瘤组织样品中至少一种免疫刺激检查点分子的表达水平，ii）比较在步骤i）中确定的表达水平与预定参考值，以及iii）在步骤i）中确定的水平高于预定参考值时得出结论，患者将有较长的生存时间，或者得出结论，患者将具有以下特征：当在步骤i）中确定的水平低于预定参考值时，生存时间短。

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