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PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD
PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD
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机译：嘧啶衍生物及其在治疗COPD等呼吸系统疾病中的用途
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摘要
The present invention is directed to compounds of formula (I)(see formula I)wherein A is C-R1; R1 and R2 are hydrogen; R4 is hydrogen; R5 is hydrogen;R3 is trifluoromethyl, 3-chloro or 3-bromo; R6 is -CO2R11; -X1X2- is -NR19-CO-;R11 represents a radical of formula -[Alk1]p-[Q]r-[Alk2]q-Z wherein p, q areindependently 0 or 1, t is 0; Alk1 and Alk2 each independently represent aC1-C6 alkylene radical; Z is (i) -N(R A)(R B) wherein R A and R B areindependentlyhydrogen, or a C1-C6-alkyl; or (ii)-N+(R A)(R B)(R C) wherein R A, R B and R Careindependently a C1-C6-alkyl; R19 is hydrogen or (C1-C6)alkyl. These compoundsareinhibitors of neutrophil elastase. The compounds of the invention andpharmaceutical compositions prepared therefrom are useful in the treatment ofdiseases and conditions in which human neutrophil elastase plays a part.
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