首页>
外国专利>
BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS
BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS
展开▼
机译：用于催化不对称加成反应的双手性手性配体
展开▼
页面导航
摘要
著录项
相似文献
摘要
pCompounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group -P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the -P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group -P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; R0 is methyl or hydroxyl, and R0 is methyl when Z1 is the -P*R0R1 group; and R1 is a C-bonded optically enriched or optically pure chiral, mono- or polycyclic, nonaromatic hydrocarbon or heterohydrocarbon radical which has 3 to 12 ring atoms and 1 to 4 rings and which has a stereogenic carbon atom at least in the a position to the P-C bond; Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations./p[WO2009065784A1]
展开▼
机译：式（I）的化合物，其以主要包含一种非对映体的混合物形式或以纯非对映体的形式，Z 1 -QP * R 0 R 1（I），其中Z 1为C键合的仲膦基-P （R）2;其中R分别独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价非手性芳族基础骨架，二价非手性二茂铁基础骨架，任选取代的二价环烷烃或杂环烷烃骨架或C 1 -C 4亚烷基骨架，并且在该骨架中，仲膦基Z 1直接键合。碳原子，或在环状基础骨架的情况下，直接连接至碳原子或通过C1-C4-亚烷基，且其中基础骨架的P-手性基团-P * R0R1直接与碳键合原子，或在环状基础骨架的情况下，直接连接至碳原子或通过C1-C4-亚烷基连接至碳原子，以使磷原子通过碳链的1至7个原子连接，并任选被杂原子中断选自O，S，N，Fe或Si; P *是手性磷原子;当Z1为-P * R0R1基团时，R0为甲基或羟基，R0为甲基; R1为C键合的光学富集或光学纯的手性，单环或多环，非芳族烃或杂烃基，其具有3至12个环原子和1至4个环并且在至少一个位置上具有立体碳原子PC键;这些配体的金属配合物是用于不对称加成反应，特别是加氢反应的均相催化剂。 [WO2009065784A1]
展开▼
