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首页> 外国专利> fusion polypeptide, nucleic acid molecule, host cell, method of producing a fusion polypeptide, use of fusion polypeptide, method for activating signaling pathways, method for co-stimulating cells, method for inducing lymphocyte proliferation, and method for direct cd137 collation

fusion polypeptide, nucleic acid molecule, host cell, method of producing a fusion polypeptide, use of fusion polypeptide, method for activating signaling pathways, method for co-stimulating cells, method for inducing lymphocyte proliferation, and method for direct cd137 collation

机译：融合多肽，核酸分子，宿主细胞，产生融合多肽的方法，融合多肽的用途，激活信号通路的方法，共刺激细胞的方法，诱导淋巴细胞增殖的方法和直接cd137核对的方法

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摘要

The disclosure provides a fusion polypeptide specific for cd137 and gpc3, the fusion polypeptide of which may be useful for directing the assembly and activation of cd137 in gpc3-positive tumor cells. Such a fusion polypeptide may be used in many pharmaceutical applications, for example, as anticancer agents and / or immune modulators for the treatment or prevention of human diseases, such as a variety of tumors. The present disclosure also relates to methods for producing the fusion polypeptide described herein, as well as compositions comprising such fusion polypeptide. The present disclosure further relates to nucleic acid molecules encoding such fusion polypeptide and methods for generating such fusion polypeptide and nucleic acid molecules. furthermore, the present application describes therapeutic and / or diagnostic uses of such fusion polypeptide, as well as compositions comprising one or more such fusion polypeptides.
机译：本公开提供了对cd137和gpc3具有特异性的融合多肽，其融合多肽可用于指导gpc3阳性肿瘤细胞中cd137的组装和激活。这样的融合多肽可以在许多药物应用中使用，例如，作为抗癌剂和/或免疫调节剂，用于治疗或预防人类疾病，例如多种肿瘤。本公开还涉及产生本文所述的融合多肽的方法，以及包含这种融合多肽的组合物。本公开进一步涉及编码这种融合多肽的核酸分子以及产生这种融合多肽和核酸分子的方法。此外，本申请描述了这种融合多肽的治疗和/或诊断用途，以及包含一种或多种这种融合多肽的组合物。

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