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Pyrimidinic derivatives inhibitors of the Enzyme dihydrofolate reductase (DHFR)
Pyrimidinic derivatives inhibitors of the Enzyme dihydrofolate reductase (DHFR)
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机译：酶二氢叶酸还原酶（DHFR）的嘧啶衍生物抑制剂
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摘要
Claim 1: A compound having the structure of formula (1) or a pharmaceutically acceptable salt or prodrug thereof, wherein: R¹ is H, C₁₋₆ alkyl,C₃₋₆ cycloalkyl,C₄₋₈ cycloalkylalkyl or halogen; W is N or CR¹⁸ and Z is N or CR¹⁷,2. The condition is that at least one of W and Z is n;R3,R830808,R83099,R8310,R8311th,R8322,R8313,R1831181 and r831222 are independent from h, acquilo c83218c833126;C₃₋₆ cycloalkyl,Hydroxyl or fluorine, provided that there are at least four rivers,R3,R830808,R83099,R8310,R8311th,R831222 and r8313sean h; if W is n, then there is no R2,R3,R8310 and r8311;If Z is n, there is no r830808,R83099,R⁸ and R⁹ is hydroxyl; R¹⁰ is substituted or unsubstituted C₆₋₁₀ aryl or 5-10 membered heteroaryl.
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