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Interferon therapeutic effect prediction method and pharmaceutical composition for treatment of hepatitis B patient using the same

机译:干扰素疗效预测方法及使用该方法的乙肝患者药物组合物

摘要

An object of the present invention is to provide a method for predicting patients in which sequential therapy with interferon therapy after treatment with a nucleic acid analog preparation is likely to be effective. The subject is (1) the step of measuring the IFN-λ3 concentration and the HBs antigen concentration of the specimen derived from an HBV-infected patient of the present invention, and (2) the measured IFN-λ3 concentration and the HBs antigen concentration are preset respectively. Interferon treatment may be effective when the IFN-λ3 concentration is higher than the cut-off value or exceeds the cut-off value and the HBs antigen concentration is lower than the cut-off value or lower than the cut-off value. It can be solved by the interferon therapeutic effect prediction method characterized by including a step of predicting high.
机译:本发明的目的是提供一种预测患者的方法,其中在用核酸类似物制剂治疗后,采用干扰素治疗的顺序治疗可能是有效的。受试者是(1)测量源自本发明的HBV感染患者的标本的IFN-λ3浓度和HBs抗原浓度的步骤,以及(2)测得的IFN-λ3浓度和HBs抗原浓度的步骤分别预设。当IFN-λ3浓度高于临界值或超过临界值且HBs抗原浓度低于临界值或低于临界值时,干扰素治疗可能有效。可以通过特征在于包括高预测步骤的干扰素治疗效果预测方法来解决。

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