首页> 外国专利> NEW AMINO ACID SEQUENCES WITH MICROBICIDAL ACTIVITY DERIVED FROM NAJA ATRA CARDIOTOXIN 1 (CTX-1)

NEW AMINO ACID SEQUENCES WITH MICROBICIDAL ACTIVITY DERIVED FROM NAJA ATRA CARDIOTOXIN 1 (CTX-1)

机译:来自眼镜蛇心菜毒素1(CTX-1)的具有抗菌活性的新氨基酸序列

摘要

New linear peptides are described with broad spectrum of action, high antimicrobial antiviral and antifungal activities, combined with other characteristics of non-toxicity and persistence of activity in unfavorable environmental conditions. The peptides of the invention have a length of 20 amino acids and the structure: A-B-C-D-E-F-G, in which: A represents a basic amino acid; B, D, F represent respectively 5, 3 and 3 amino acids, chosen from the group of hydrophobic amino acids; C, E represent 3 amino acids, where each C and E comprises at least one basic amino acid and at least 1 amino acid forming hydrogen bonds; G represents 2 amino acids, chosen from basic amino acids and/or hydrophobic amino acids, their salts and/or mixtures thereof.
机译:描述了具有宽范围作用,高抗微生物抗病毒和抗真菌活性,以及​​在不利的环境条件下无毒和活性持续的其他特征的新型线性肽。本发明的肽具有20个氨基酸的长度,并且结构为:A-B-C-D-E-F-G,其中:A代表碱性氨基酸; B,D,F分别代表5、3和3个氨基酸,选自疏水性氨基酸; C,E代表3个氨基酸,其中每个C和E包括至少一个碱性氨基酸和至少1个形成氢键的氨基酸; G代表2个氨基酸,选自碱性氨基酸和/或疏水性氨基酸,它们的盐和/或它们的混合物。

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