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首页> 外国专利> METHOD TO OBTAIN OPTIMIZED SOLID GENE-ACTIVATED MATERIAL, METHOD TO OBTAIN SOLID CARRIER MATRIX, OPTIMIZED SOLID GENE-ACTIVATED MATERIAL FOR TISSUE REGENERATION

METHOD TO OBTAIN OPTIMIZED SOLID GENE-ACTIVATED MATERIAL, METHOD TO OBTAIN SOLID CARRIER MATRIX, OPTIMIZED SOLID GENE-ACTIVATED MATERIAL FOR TISSUE REGENERATION

机译：获取优化的固态基因激活材料的方法，获取固态的载体矩阵，组织再生的优化的固态基因激活的材料

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FIELD: biotechnology.;SUBSTANCE: method for production of an optimized solid gene-activated material is described, comprising creation of a carrier matrix that binds at least one nucleic acid molecule, followed by placing at least one additional nucleic acid molecule on its surface by any physical method allowing such placement without chemical bond formation between the said carrier matrix and the additional nucleic acid. Also a process for preparation of a solid carrier matrix used in the method described and intended for binding of at least one nucleic acid molecule, comprising introduction of any complexing agent into the solid matrix carrier at the stage of its synthesis by treating the initial material with a solution containing a metal-complexing agent salt capable of binding of at least one nucleic acid molecule is provided. Products obtained by these methods are presented as well.;EFFECT: invention allows to receive optimized osteoplastic materials having an accurate dose of nucleic acids, more efficient dynamics of gene structures release from carrier matrix structure and increased level of recipient bed cells transfection by the biologically active substance.;5 cl, 5 dwg, 2 tbl, 2 ex
机译：技术领域：描述了一种用于生产优化的固体基因激活材料的方法，该方法包括产生与至少一个核酸分子结合的载体基质，随后通过将至少一个另外的核酸分子置于其表面上，允许这种放置而在所述载体基质和另外的核酸之间不形成化学键的任何物理方法。也是一种用于所述方法中并旨在结合至少一个核酸分子的固体载体基质的制备方法，包括在其合成阶段通过用下列物质处理初始物质将任何络合剂引入到固体基质载体中。提供了一种溶液，该溶液包含能够与至少一个核酸分子结合的金属络合剂盐。还介绍了通过这些方法获得的产品。效果：本发明允许接收具有精确剂量核酸，更有效地从载体基质结构释放基因结构的动力学以及通过生物学方法提高受体床细胞转染水平的优化骨塑性材料。活性物质。; 5 cl，5 dwg，2 tbl，2 ex

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