首页> 外国专利> 2,8-DIAZASPIRO4,5DECAN-1-ONE DERIVATIVES, USEFUL AS INHIBITORS OF HORMONE-SENSITIVE LIPASE (HSL)

2,8-DIAZASPIRO4,5DECAN-1-ONE DERIVATIVES, USEFUL AS INHIBITORS OF HORMONE-SENSITIVE LIPASE (HSL)

机译：2,8-二氮杂螺[4,5] DECAN-1-ONE衍生物，可用作激素敏感脂酶（HSL）的抑制剂

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FIELD: chemistry.;SUBSTANCE: invention relates to organic chemistry and specifically to novel 2,8-diazaspiro[4.5]decan-1-one derivatives or pharmaceutically acceptable salts thereof, where R¹ is selected from phenyl, which is substituted with one substitute selected from halogen-C_1-4-alkoxy; R² is selected from phenyl, pyridinyl and 2-oxo-1,2-dihydro-pyridinyl, which are substituted with one or two substitutes independently selected from C_1-4-alkyl, halogen, halogen-C_1-4-alkyl, hydroxy, C_1-4-alkoxy, halogen-C_1-4-alkoxy and benzyloxy; n equals zero. Invention also refers to a pharmaceutical composition based on the compound of formula (I).;EFFECT: obtaining novel 2,8-diazaspiro[4,5]decan-1-one derivatives inhibiting hormone-sensitive lipase (HSL).;12 cl, 20 ex

机译：发明领域本发明涉及有机化学，尤其涉及新颖的2,8-二氮杂螺[4.5]癸康-1-酮衍生物或其药学上可接受的盐，其中R ^{1 选自苯基，其被选自卤素-C _{1-4 -烷氧基的一种取代基取代; R ^{2 选自苯基，吡啶基和2-氧代-1,2-二氢吡啶基，它们被一个或两个独立地选自C _{1-4 的取代基取代-烷基，卤素，卤素-C _{1-4 -烷基，羟基，C _{1-4 -烷氧基，卤素-C _{1-4 -烷氧基和苄氧基; n等于零。本发明还涉及基于式（I）的化合物的药物组合物。效果：获得抑制激素敏感性脂肪酶（HSL）的新的2,8-二氮杂螺[4,5] decan-1-one衍生物。，20前}}}}}}}

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公开/公告号RU2606513C2

专利类型
公开/公告日2017-01-10

原文格式PDF
申请/专利权人 F. HOFFMANN-LA ROCHE AG;
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申请/专利号RU20130108748
发明设计人 AKKERMANN ZHAN (CH);KONTE AURELIYA (CN);KHUNTSIKER DANIEL (CH);NAJDKHART VERNER (FR);NETTEKOFEN MATTIAS (DE);SHULTS-GASH TANYA (CH);VERTAJMER STENLI (US);
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申请日2011-08-10
分类号C07D471/10;A61K31/438;A61P3/04;A61P3/10;A61P9/10;
国家 RU
入库时间 2022-08-21 13:23:45

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