首页>
外国专利>
Reprogramming effector protein interactions to correct epigenetic defects in cancer
Reprogramming effector protein interactions to correct epigenetic defects in cancer
展开▼
机译:重新编程效应蛋白相互作用以纠正癌症的表观遗传缺陷
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods of "reprogramming" epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.
展开▼