首页> 外国专利> Reprogramming effector protein interactions to correct epigenetic defects in cancer

Reprogramming effector protein interactions to correct epigenetic defects in cancer

机译：重新编程效应蛋白相互作用以纠正癌症的表观遗传缺陷

页面导航

摘要
著录项
相似文献

摘要

Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.

机译：提供了对表观遗传标记读取器或擦除器进行“重新编程”以识别其同源（或自然）标记以外的表观遗传标记的方法。重新编程读取器或橡皮擦可以抵消可能导致某些疾病状态（例如癌症）的异常写入器活动（例如，功能丧失或活动过度）的影响。还提供了通过这些方法鉴定的重编程化合物在此类疾病状态的治疗中的用途。这些方法可以作为目标的标记阅读器包括BPTF和CBX2。

著录项

公开/公告号US9552457B2

专利类型
公开/公告日2017-01-24

原文格式PDF
申请/专利权人 BRITISH COLUMBIA CANCER AGENCY BRANCH;
展开▼

申请/专利号US201314381588
发明设计人 STEVEN J. M. JONES;OLEKSANDR YAKOVENKO;SILVIA THOENE;PIERRE YULMIN CHEUNG;JIANGHONG AN;
展开▼

申请日2013-02-27
分类号G06F19/16;A61K31/137;A61K31/47;A61K31/46;A61K31/10;A61K31/135;A61K31/167;A61K31/245;A61K31/36;A61K31/407;A61K31/5375;C40B30/02;G06F19;A61K31/343;A61K31/4709;
国家 US
入库时间 2022-08-21 13:42:45

相似文献

专利
外文文献
中文文献