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Use of molecular chaperones for enhanced production of recombinant secreted proteins in mammalian cells

机译:分子伴侣在哺乳动物细胞中增强重组分泌蛋白产生的用途

摘要

A mammalian host cell for enhanced expression of a recombinant protein product, said mammalian cell having genetic material encoding the expression of said recombinant protein product and transformed with at least one expression vector comprising DNA encoding the calnexin chaperone protein, wherein said recombinant protein product is Factor VIII.
机译:一种用于增强重组蛋白产物表达的哺乳动物宿主细胞,所述哺乳动物细胞具有编码所述重组蛋白产物表达的遗传材料,并用至少一种包含编码骨钙素伴侣蛋白的DNA的表达载体转化,其中所述重组蛋白产物是因子八。

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