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Deficit of growth hormone receptors as a cause of a significant reduction in pro-aging signaling, cancer and diabetes
Deficit of growth hormone receptors as a cause of a significant reduction in pro-aging signaling, cancer and diabetes
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机译:生长激素受体不足是导致衰老信号,癌症和糖尿病的显着减少的原因
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摘要
A GH / IGF-1 axis inhibitor composition, for use in a method to alleviate a side effect of chemotherapy in a subject, the method comprising: identifying a subject undergoing chemotherapy; administering to the subject a therapeutically effective amount of a GH / IGF-1 axis inhibitor composition and measuring the level of IGF-1 in the subject; wherein the GH / IGF-1 axis inhibitor composition comprises a variant of human growth hormone that includes at least one amino acid substitution selected from the group consisting of H18D, H21N, R167N, K168A, D171S, K172R, E174S, I179T and G120R or a recombinant analog of 191 amino acids of the GH protein having added polyethylene glycol groups.
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