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Deficit of growth hormone receptors as a cause of a significant reduction in pro-aging signaling, cancer and diabetes

机译:生长激素受体不足是导致衰老信号,癌症和糖尿病的显着减少的原因

摘要

A GH / IGF-1 axis inhibitor composition, for use in a method to alleviate a side effect of chemotherapy in a subject, the method comprising: identifying a subject undergoing chemotherapy; administering to the subject a therapeutically effective amount of a GH / IGF-1 axis inhibitor composition and measuring the level of IGF-1 in the subject; wherein the GH / IGF-1 axis inhibitor composition comprises a variant of human growth hormone that includes at least one amino acid substitution selected from the group consisting of H18D, H21N, R167N, K168A, D171S, K172R, E174S, I179T and G120R or a recombinant analog of 191 amino acids of the GH protein having added polyethylene glycol groups.
机译:一种GH / IGF-1轴抑制剂组合物,用于减轻受试者的化学疗法的副作用的方法,所述方法包括:鉴定正在接受化学疗法的受试者;向受试者施用治疗有效量的GH / IGF-1轴抑制剂组合物并测量受试者中IGF-1的水平;其中GH / IGF-1轴抑制剂组合物包含人类生长激素的变体,其包含选自H18D,H21N,R167N,K168A,D171S,K172R,E174S,I179T和G120R的至少一种氨基酸取代或具有添加的聚乙二醇基团的GH蛋白的191个氨基酸的重组类似物。

著录项

  • 公开/公告号ES2632348T3

    专利类型

  • 公开/公告日2017-09-12

    原文格式PDF

  • 申请/专利权人 UNIVERSITY OF SOUTHERN CALIFORNIA;

    申请/专利号ES20110777722T

  • 发明设计人 LONGO VALTER D.;GUEVARA JAIME;

    申请日2011-01-21

  • 分类号A61K39;A61K38/27;A61K39/395;C07K16/26;C07K16/28;

  • 国家 ES

  • 入库时间 2022-08-21 13:35:11

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