首页> 外国专利> Pyridine-based isocyanides as novel reagents for multicomponent reactions.

Pyridine-based isocyanides as novel reagents for multicomponent reactions.

机译：吡啶基异氰酸酯是用于多组分反应的新型试剂。

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摘要

The present invention provide novel substituted 2-isocyanopyridines and their use in methods comprising reacting substituted isocyanopyridines of the general formula with a carbonyl-containing compound selected from the group consisting of an aldehyde and a ketone; in the presence of an acidic carbon compound selected from the group consisting of a carboxylic acid and a (thio)phenolic compound and/or a primary or secondary amine, including their use in Ugi, Passerini and Ugi-Smiles reactions, and conversion of the resulting secondary amide products to (thio)carboxylic acids, (thio)esters and amides.

机译：本发明提供了新颖的取代的2-异氰基吡啶及其在方法中的用途，所述方法包括使通式的取代的异氰基吡啶与选自醛和酮的含羰基化合物反应;在选自羧酸和（硫代）酚化合物和/或伯胺或仲胺的酸性碳化合物的存在下，包括它们在Ugi，Passerini和Ugi-Smiles反应中的用途，以及得到的仲酰胺产物为（硫代）羧酸，（硫代）酯和酰胺。

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公开/公告号NL2015814B1

专利类型
公开/公告日2017-06-06

原文格式PDF
申请/专利权人 STICHTING VU-VUMC;
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申请/专利号NL20152015814
发明设计人 EELCO RUIJTER;ROMANO VINCENZO ANTONIO ORRU;JACOBUS ADRIANUS WILHELMUS JONG;GYDO VAN DER HEIJDEN;
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申请日2015-11-19
分类号C07D213/72;C07D213/75;
国家 NL
入库时间 2022-08-21 13:37:23

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