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PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE.
PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE.
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机译:潜在滥用可能性低的聚乙二醇化阿片类药物。
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摘要
The invention provides opioid agonists covalently bound to a water-soluble oligomer having reduced potential for substance abuse and uses thereof. The compounds of the invention possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist associated with certain alternative delivery formulations.
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