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PEGYLATED OPIOIDS WITH LOW POTENTIAL FOR ABUSE.

机译:潜在滥用可能性低的聚乙二醇化阿片类药物。

摘要

The invention provides opioid agonists covalently bound to a water-soluble oligomer having reduced potential for substance abuse and uses thereof. The compounds of the invention possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist associated with certain alternative delivery formulations.
机译:本发明提供了与水溶性低聚物共价结合的阿片样物质激动剂,其具有降低的物质滥用潜力以及其用途。相对于单独的阿片样物质激动剂,本发明的化合物具有改变的药代动力学特征,但是没有遭受物理篡改的风险,所述物理篡改的风险允许回收和滥用与某些替代递送制剂有关的阿片样物质激动剂。

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