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首页> 外文会议>ASMS Conference on Mass Spectrometry and Allied Topics >QTRAP LC/MS/MS Workflow for Simultaneous Characterization and Quantitation of PEGylated Liposomal Drug Formulation Characterization of precursor lipids and its PEGylated derivatives allows the determination of liposome compositions using QTRAP LC/MS/MS System
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QTRAP LC/MS/MS Workflow for Simultaneous Characterization and Quantitation of PEGylated Liposomal Drug Formulation Characterization of precursor lipids and its PEGylated derivatives allows the determination of liposome compositions using QTRAP LC/MS/MS System

机译：Qtrap LC / MS / MS工作流程用于同时表征和定量前体脂质的表征及其聚乙二醇化衍生物允许使用Qtrap LC / MS / MS系统测定脂质体组合物

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Liposomes are used to encapsulate pharmacological active compounds for drug delivery. In order to improve the circulation time of liposomes in the blood stream, lipids can be conjugated with low molecular weight PEG. It is important to accurately determine a liposomes molecular composition, because it may be composed of different lipids to modulate its properties. Although amount and ratio of the starting materials for the synthesis of liposomes are known, the lipid composition of the product may not reflect input quantities. We describe the qualitative and quantitative analysis of liposomes composed of PEG-2000-conjugated and unconjugated phospholipids by LC-MS/MS analysis using a QTRAP 5500, and the data analysis using PeakView and MultiQuant software. The method allows the determination of liposome compositions.
机译：脂质体用于包封用于药物活性化合物的药物递送。为了改善血液流中脂质体的循环时间，脂质可以与低分子量PEG缀合。重要的是准确地确定脂质体分子组合物，因为它可以由不同的脂质组成以调节其性质。尽管已知用于合成脂质体的原料的量和比例，但产品的脂质组合物可能不反映输入量。通过使用Qtrap 5500，通过LC-MS / MS分析描述由LC-MS / MS分析的PEG-2000-缀合和未缀合的磷脂组成的脂质体的定性和定量分析，以及使用PeakView和多仲软件的数据分析。该方法允许测定脂质体组合物。

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