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首页> 美国政府科技报告 >Novel Method for the Determination of Sildenafil (Viagra) and Its Metabolite (UK-103,320) in Postmortem Specimens Using LC/MS/MS and LC/MS/MS/MS
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Novel Method for the Determination of Sildenafil (Viagra) and Its Metabolite (UK-103,320) in Postmortem Specimens Using LC/MS/MS and LC/MS/MS/MS

机译：使用LC / ms / ms和LC / ms / ms / ms测定死后标本中西地那非（伟哥）及其代谢物（UK-103,320）的新方法

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摘要

During the investigation of aviation accidents, postmortem samples from victimsare submitted to the FAA's Civil Aeromedical Institute for drug analysis. Because new drugs are continually being released to the market, it is our laboratory's responsibility to develop methods which can identify these new drugs. This paper presents a rapid and reliable method for the identification and quantitation of sildenafil (Viagra ) and its metabolite, UK-103,320. Sildenafil, when used properly, is relatively safe. There are, however, certain side effects that could create potential hazards. For example, Sildenafil has been shown to potentiate the hypotensive effects of nitrates commonly employed in the treatment of certain heart conditions. The procedure described herein incorporates solid-phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization (APCI) ion trap mass spectrometer (MS) in the positive ionization (PCI) mode. During the investigation of aviation accidents, postmortem samples from victims are submitted to the FAA's Civil Aeromedical Institute for drug analysis. Because new drugs are continually being released to the market, it is our laboratory's responsibility to develop methods which can identify these new drugs.

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