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FLAVONOID GLYCOSIDE FOR PLATELET AGGREGATION INHIBITORY AND THROMBOLYTIC AGENT FROM CITRUS LIMON (L.) OSBECK
FLAVONOID GLYCOSIDE FOR PLATELET AGGREGATION INHIBITORY AND THROMBOLYTIC AGENT FROM CITRUS LIMON (L.) OSBECK
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机译：黄酮糖苷用于柠檬柠檬石的血小板聚集抑制和血栓形成剂
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摘要
In traditional practice, Citrus limon showed to have a potential effect in number of conditions connected with cardiovascular diseases. Many cardiovascular diseases can be accredited to excessive platelet aggregation, which has a vital role in thrombus formation. The present invention relates to the platelet aggregation inhibition and thrombolytic activity of aqueous ethanolic fruit peel extract of Citrus limon and the bioactive flavanoid glycoside, 3, 5, 7-trihydroxy-4-methoxyflavone-7-rutinoside. The extract and compound exhibited a dose dependent inhibitory activity on platelet aggregation induced by the agonist, ADP with significant thrombolytic effect. The concentrations of bioactive compound required for 50% platelet aggregation reduction and thrombolysis were 15.73 Hg/mL and 79.01 jxg/mL, respectively. Therefore, the isolated bioactive flavanoid glycoside, 3 5, 7-trihydroxy-4-methoxyflavone-7- rutinoside can be considered as potential alternative phytochemical drug to develop formulations as platelet aggregation inhibitor and thrombolytic agent.
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