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compound, composition, method of inhibiting amine oxidase activity aoss / pav-1, method of treating a disease associated with or modulated by aoss / pav-1 and use of a compound

机译：化合物，组合物，抑制aoss / pav-1的胺氧化酶活性的方法，治疗与aoss / pav-1相关或受其调节的疾病的方法以及该化合物的用途

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Summary "compound, composition, method of inhibiting amine oxidase activity aoss / pav-1, method of treating a disease associated with or modulated by aoss / pav-1 and use of a compound" The present invention relates to the preparation and the use of substituted 3-haloallylamine derivatives as aoss / pav-1 inhibitors having the structure of formula i as defined in the descriptive report. The present invention also relates to methods of using the compounds of formula I or pharmaceutically acceptable salts or derivatives thereof for treating a number of indications, for example inflammatory diseases, eye diseases, fibrotic diseases, diabetes-induced diseases and cancer. .

机译：发明内容“化合物，组成，抑制aoss / pav-1的胺氧化酶活性的方法，治疗与aoss / pav-1相关的疾病或由aoss / pav-1调节的疾病的方法和化合物的用途”本发明涉及药物的制备和用途。取代的3-卤代烯丙胺衍生物作为aoss / pav-1抑制剂，具有描述性报告中定义的式i的结构。本发明还涉及使用式I化合物或其药学上可接受的盐或衍生物治疗多种适应症的方法，所述多种适应症例如炎性疾病，眼病，纤维化疾病，糖尿病诱导的疾病和癌症。。

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公开/公告号BR112014027406A2

专利类型
公开/公告日2017-06-27

原文格式PDF
申请/专利权人 PHARMAXIS LTD.;
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申请/专利号BR20141127406
发明设计人 ALAN ROBERTSON;ALISON DOROTHY FINDLAY;CRAIG IVAN TURNER;IAN ALEXANDER MCDONALD;JONATHAN STUART FOOT;MANDAR DEODHAR;WOLFGANG JAROLIMEK;
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申请日2013-04-05
分类号A61K31/18;A61K31/166;A61P29;C07C233/11;C07C311/16;
国家 BR
入库时间 2022-08-21 13:40:23

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