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PREDICTION OF RESPONSE TO PARP INHIBITORS AND COMBINATIONAL THERAPY TARGETING C-MET AND PARP1

机译：预测对PARP抑制剂的反应以及靶向联合C-MET和PARP1的治疗

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摘要

Provided herein are methods for identifying and treating cancers that are resistant to PARP inhibition. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. In some aspects. PARP inhibitor cancers are treated with a PARP inhibitor therapy in combination with a c-Met inhibitor therapy.

机译：本文提供了鉴定和治疗对PARP抑制有抗性的癌症的方法。还提供了使癌症对PARP抑制剂疗法敏感的方法。在某些方面。使用PARP抑制剂疗法与c-Met抑制剂疗法相结合可治疗PARP抑制剂癌症。

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公开/公告号US2017219565A1

专利类型
公开/公告日2017-08-03

原文格式PDF
申请/专利权人 BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;
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申请/专利号US201515514928
发明设计人 MIEN-CHIE HUNG;YI DU;
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申请日2015-09-29
分类号G01N33/50;C12M1/34;C12M1;C12M1/26;A61K35/28;C12N5/0775;C12N5;C12N5/079;B01L3;G01N33/569;C12M1/32;
国家 US
入库时间 2022-08-21 13:49:53

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