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Lung cancer patient therapeutic agent and method for predicting the effectiveness of lung cancer patient treatment

机译:肺癌患者治疗剂和预测肺癌患者治疗效果的方法

摘要

Provided are a lung cancer therapeutic agent for treating a lung cancer patient, in particular, an NSCLC patient having resistance to EGFR-TKI, and a predictive test method for the effectiveness of the lung cancer patient treatment. As a result of earnest examination of therapeutic agents for lung cancer patients with an optimal combination of HDAC inhibitor and EGFR-TKI, `` If BIM in the sample derived from NSCLC patients resistant to EGFR-TKI is non-wild type, EGFR -TKI monotherapy is less effective, but it is effective for treatment of lung cancer patients combined with JNJ-26481585 and EGFR-TKI or lung cancer patients combined with CUDC-101 and EGFR-TKI The present invention has been completed.
机译:提供了用于治疗肺癌患者,特别是对EGFR-TKI具有抗性的NSCLC患者的肺癌治疗剂,以及用于肺癌患者治疗的有效性的预测测试方法。认真检查了具有HDAC抑制剂和EGFR-TKI最佳组合的肺癌患者的治疗药物,``如果源自NSCLC患者的EGFR-TKI耐药样品中的BIM是非野生型,则EGFR -TKI单一疗法效果较差,但对于联合JNJ-26481585和EGFR-TKI的肺癌患者或与CUDC-101和EGFR-TKI组合的肺癌患者有效。本发明已经完成。

著录项

  • 公开/公告号JPWO2016032003A1

    专利类型

  • 公开/公告日2017-07-13

    原文格式PDF

  • 申请/专利权人 国立大学法人金沢大学;

    申请/专利号JP20160545662

  • 发明设计人 矢野 聖二;竹内 伸司;

    申请日2015-08-31

  • 分类号A61K31/506;A61P43;A61P35;A61P11;A61K31/5377;A61K45;A61K31/517;C12N15/113;C12Q1/68;C12N9/99;G01N33/574;

  • 国家 JP

  • 入库时间 2022-08-21 13:54:04

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