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Treatment of familial exudative vitreoretinopathy by inhibition of S1PR2

机译:抑制S1PR2治疗家族性渗出性玻璃体视网膜病变

摘要

Methods and compositions for treating familial exudative vitreoretinopathy (FEVR) and retinopathy of prematurity (ROP) by administering a therapeutically effective amount of a sphingosine-1-phosphate receptor type 2 (S1PR2) inhibitor Things are provided. In one aspect, administering a pharmaceutical composition comprising a therapeutically effective amount of an S1PR2 inhibitor, an amount of at least one buffer sufficient to reduce degradation of the S1PR2 inhibitor, to reduce retinal vascular disorders in a patient. A method of treating is provided.
机译:提供了通过治疗有效量的2型鞘氨醇-1-磷酸受体(S1PR2)抑制剂来治疗家族性渗出性玻璃体视网膜病变(FEVR)和早产儿视网膜病变(ROP)的方法和组合物。一方面,施用药物组合物,其包含治疗有效量的S1PR2抑制剂,一定量的至少一种缓冲剂,其足以减少S1PR2抑制剂的降解,以减少患者的视网膜血管疾病。提供了一种治疗方法。

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