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METHODS AND MEANS FOR MANAGING EXTENDED-SPECTRUM BETA-LACTAMASE (ESBL)-PRODUCING ENTEROBACTERIACEAE COLONIZATION

机译：广谱β-内酰胺酶（ESBL）生产肠杆菌科定殖的方法和手段

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摘要

The present invention relates to the field of the management of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae colonization. In particular, the present invention relates to methods for assessing the risk to develop intestinal carriage of ESBL-producing Enterobacteriaceae (E-ESBL) or for prognosing intestinal carriage of E-ESBL. More specifically, the invention relates to methods comprising a step of determining the abundance of at least one bacterium selected from the list consisting of bacteria from the genus Desulfovibrio, Oscillospira, Parabacteroides, Coprococcus and Prevotella in the gut microbiota of a subject.;A further object of this invention is to provide a new composition, for mucosal administration, comprising at least one bacterium selected from the list consisting of bacteria from the genus Desulfovibrio, Oscillospira, Parabacteroides, and Coprococcus. More particularly, this invention relates to such compositions for use in the prevention or treatment of intestinal carriage of E-ESBL in a subject in need thereof.

机译：本发明涉及产生广谱β-内酰胺酶（ESBL）的肠杆菌科定植的管理领域。特别地，本发明涉及评估产生ESBL的肠杆菌科细菌（E-ESBL）发展为肠运输的风险或预测E-ESBL的肠运输的风险的方法。更具体地，本发明涉及包括确定选自以下的至少一种细菌的丰度的方法：选自以下的细菌：脱硫弧菌属，颤藻属，副细菌属，副球菌属和副球菌属。本发明的另一个目的是提供一种用于粘膜给药的新组合物，其包含至少一种选自以下的细菌：脱硫弧菌属，颤菌属的细菌。更具体地，本发明涉及用于在需要其的受试者中预防或治疗E-ESBL的肠运输的此类组合物。 展开▼

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公开/公告号EP3095877A1

专利类型

公开/公告日2016-11-23

原文格式PDF

申请/专利权人 UNIVERSITAT DE VALÈNCIA;FUNDACIÓN PARA EL FOMENTO DE LA INVESTIGACIÓN SANITARIA Y BIOMEDICA DE LA COMUNITAT VALENCIANA;CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED;UNIVERSITÉ PARIS DIDEROT - PARIS 7;ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS;
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申请/专利号EP20150305758

发明设计人 RUPPE ETIENNE;DJOSSOU FÉLIX;ANGEBAULT CÉCILE;LATORRE AMPARO;GOSALBES MARIA JOSÉ;MOYA ANDRÉS;VAZQUEZ CASTELLANOS JORGE F.;ANDREMONT ANTOINE;WOERTHER PAUL LOUIS;
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申请日2015-05-20

分类号C12Q1/68;

国家 EP

入库时间 2022-08-21 14:02:24

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