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METHODS FOR GENETICALLY DIVERSIFIED STIMULUS-RESPONSE BASED GENE ASSOCIATION STUDIES
METHODS FOR GENETICALLY DIVERSIFIED STIMULUS-RESPONSE BASED GENE ASSOCIATION STUDIES
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机译:基于遗传刺激反应的基因关联研究方法
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摘要
Methods are provided for improving the impact of genetically diversified stimulus response gene association (GDSRGA) studies. The methods may involve developing subpopulations to be contrasted in GDSRGA studies by obtaining a biological sample from each donor of a population of donors; selecting a common cohort from the biological samples by obtaining at least a partial genomic sequence from each biological sample, aligning the sequences of the biological samples, and removing biological samples that cannot be sequenced accurately or fail to align; applying a test molecule or condition to the biological samples to induce phenotypically distinct responses among the members of the cohort; and segregating the biological samples into subpopulations based on the phenotypically distinct responses. These subpopulations may be used in GDSRGA studies.
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