首页> 外国专利> METHOD FOR PREDICTION OF RISK OF UNFAVOURABLE OUTCOME IN PATIENTS WITH ACUTE CORONARY SYNDROME AND CONCOMITANT TYPE 2 DIABETES MELLITUS

METHOD FOR PREDICTION OF RISK OF UNFAVOURABLE OUTCOME IN PATIENTS WITH ACUTE CORONARY SYNDROME AND CONCOMITANT TYPE 2 DIABETES MELLITUS

机译:预测急性冠状动脉综合征和合并2型糖尿病患者不良结局的风险的方法

摘要

FIELD: medicine.SUBSTANCE: immune response factors: CRP (C-reactive protein), interleukins-1?, -4, -6, -10 (IL-1?, IL-4, IL-6, IL-10), tumour necrosis factor ? (TNF?), marker of atherosclerotic plaque destabilisation - soluble form of CD40 ligand (sCD40L) and markers of endothelial dysfunction - C-natriuretic peptide (CNP) and angiotensin-II (AT-II) are measured in blood serum. A presented mathematical model is used to calculate a prediction coefficient of the risk of the unfavourable outcome. If the derived coefficient is K0.15, the risk of the unfavourable outcome is considered to be high, whereas the derived coefficient K0.15 makes it possible to state the low risk of the unfavourable outcome. The presented method provides the more accurate prediction of the risk of the unfavourable outcomes during twelve months in the patients after an episode of acute coronary syndrome with concomitant type 2 diabetes mellitus; it can be used for an individual approach to each patient depending on the form of the disease.EFFECT: method requires no additional equipment and specially trained personnel; it is simple and easy to implement.2 ex, 1 tbl
机译:领域:医学。物质:免疫反应因子:CRP(C反应蛋白),白介素-1?,-4,-6,-10(IL-1?,IL-4,IL-6,IL-10),肿瘤坏死因子? (TNFα),动脉粥样硬化斑块失稳的标志物-CD40配体的可溶形式(sCD40L)和内皮功能障碍的标志物-C-钠尿肽(CNP)和血管紧张素II(AT-II)在血清中测量。提出的数学模型用于计算不利结果风险的预测系数。如果得出的系数K> 0.15,则认为不利结果的风险较高,而得出的系数K <0.15则可以说明发生不利结果的风险较低。所提出的方法可以更准确地预测急性冠脉综合征伴发2型糖尿病患者在12个月内不良结局的风险。效果:该方法不需要额外的设备和经过专门培训的人员;根据疾病的形式,它可以用于针对每个患者的单独治疗。它很容易实现。2ex,1 tbl

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