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H Marker and Kit for Diagnosising and Distingushing Aspirin exacerbated respiratory diseases and Aspirin tolerant asthma
H Marker and Kit for Diagnosising and Distingushing Aspirin exacerbated respiratory diseases and Aspirin tolerant asthma
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机译：诊断和区分阿司匹林加重的呼吸系统疾病和阿司匹林耐受性哮喘的H标志物和试剂盒
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摘要
The present invention relates to aspirin induced respiratory disease (AERD) and aspirin resistant asthma (ATA) distinct diagnostic marker composition and a diagnostic kit comprising a plasma apolipoprotein H. ApoH identify the person in AERD between ATA and plasma, ELISA was performed to quantify. 8 protein spots AERD ( n = 8) and ATA ( n = 8) showed a difference in the relative strength of the subjects across the collected plasma. MALDI-TOF / TOF analysis of alpha in AERD compared with ATA - Avoid debris no rps precursor, Apo H, fibrin beta (fibrin beta) and pro-level reduction in apolipoprotein (proapolipoprotein) and the chain A of complement components (chain A human complement component) C3, 90-kDa heat shock protein, complement components, C4a and key Nino Gen (kininogen) -1 showed the variants (isoform) 2 increased. Apo H density ELISA measurements ( P 0.01), were significantly increased in the plasma of subjects than ATA AERD and normal control group. AERD are characterized by changes in protein levels associated with the clot and the complement path. In addition, Apo H is increased as compared with the ATA AERD and normal control group, indicating that the cause of the disease is associated with other Apo H AERD with ATA. ;
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机译：本发明涉及阿司匹林诱发的呼吸道疾病（AERD）和阿司匹林抵抗性哮喘（ATA）的独特诊断标记物组合物以及包含血浆载脂蛋白H的诊断试剂盒。ApoH在ATA和血浆之间鉴定出AERD中的人，进行了ELISA以定量。 8个蛋白斑点AERD（ n = 8）和ATA（ n = 8）在整个血浆中显示出受试者相对强度的差异。相对于ATA的AERD中α的MALDI-TOF / TOF分析-避免无碎片的rps前体，Apo H，血纤蛋白β（血纤蛋白β）和载脂蛋白（proapolipoprotein）和补体成分链A的亲水平降低（链A人补体成分）C3、90 kDa热激蛋白，补体成分C4a和关键Nino Gen（激肽原）-1显示变体（异构体）2增加。与ATA AERD和正常对照组相比，受试者血浆中的Apo H密度ELISA测量（ P <0.01）显着增加。 AERD的特征是与凝块和补体途径有关的蛋白质水平变化。此外，与ATA AERD和正常对照组相比，Apo H升高，表明该疾病的原因与其他ATA的Apo H AERD有关。 ;
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