首页> 外国专利> DIAGNOSIS METHOD OF COLON CANCER FOR RAPID COLONOSCOPY USING MULTIPLEXED FLUORESCENT QUANTUM DOT-ANTIBODY COMPLEX PROBE

DIAGNOSIS METHOD OF COLON CANCER FOR RAPID COLONOSCOPY USING MULTIPLEXED FLUORESCENT QUANTUM DOT-ANTIBODY COMPLEX PROBE

机译：多重荧光量子点-抗体复合物探针快速结肠镜诊断结肠癌的方法

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摘要

The present invention relates to a diagnostic device for colon cancer using quantum dots and, more specifically, to a device and a method for diagnosing colon cancer using a multiplexed fluorescent-antibody complex probe capable of quickly diagnosing colon cancer. The diagnostic method in accordance with the present invention features of labeling a colon tissue with a multiplexed fluorescent quantum dot-antibody complex probe, which is formed by binding an antibody to multiplexed fluorescent quantum dots modified with an amphoteric ion composite, so as to fluoresce. The present invention provides the multiplexed fluorescent quantum dot-antibody complex probe capable of labeling cancer by a single spray and wash (& wash′) method. The probe can be used for colon cancer diagnosis using colonoscopy, and can detect squamous carcinoma, which is hard to find by the naked eye when colonoscopy is performed, and adenocarcinoma, which is not rapidly progressed yet. In addition, as quantum dots absorb light in a wide range and have a narrow range of light emitting spectrum, thereby reducing the diagnostic error rate which can occur when only one probe is used, by treating various cancer target substances with the quantum dots having different fluorescence wavelengths at the same time. Therefore colon cancer can be detected with high reliability.;COPYRIGHT KIPO 2016

机译：结肠癌的诊断装置技术领域本发明涉及使用量子点的结肠癌的诊断装置，更具体地，涉及使用能够快速诊断结肠癌的多重荧光抗体复合探针的结肠癌的诊断装置及方法。根据本发明的诊断方法的特征在于用多重荧光量子点-抗体复合物探针标记结肠组织，该探针是通过将抗体与经两性离子复合物修饰的多重荧光量子点结合从而发荧光而形成的。本发明提供了能够通过单次喷雾和洗涤（＆wash＆prime;）方法标记癌症的多重荧光量子点-抗体复合物探针。该探针可用于通过结肠镜检查进行结肠癌诊断，并可检测进行结肠镜检查时用肉眼难以发现的鳞状癌和尚未迅速发展的腺癌。另外，由于量子点吸收大范围的光并且具有窄范围的发光光谱，从而通过用具有不同的量子点处理各种癌靶物质来降低仅使用一种探针时可能发生的诊断错误率。荧光波长在同一时间。因此可以高度可靠地检测出结肠癌。; COPYRIGHT KIPO 2016

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公开/公告号KR20160046933A

专利类型
公开/公告日2016-05-02

原文格式PDF
申请/专利权人 POSTECH ACADEMY-INDUSTRY FOUNDATION;
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申请/专利号KR20140141447
发明设计人 DO EUN JUKR;KIM KI HEANKR;BEA SANG MUNKR;CHUNG EUI HEONKR;PARK JOON HYUCKKR;KIM JAE ILKR;RYU YEON MIKR;KIM SANG YEOBKR;PARK YOUNG RONGKR;KIM SUNG JEEKR;HWANG SE KYUKR;WANG TAE JUNKR;MYUNG SEUNG JAEKR;JUNG YE BINKR;BAEK YEONG GYEONGKR;YOON YEO REUMKR;
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申请日2014-10-20
分类号G01N33/533;A61B1/31;G01N33/574;
国家 KR
入库时间 2022-08-21 14:14:33

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