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NATURALLY-DERIVED COMPOSITIONS FROM CALAMUS ORNATUS FOR ANTI-INFLAMMATORY APPLICATIONS

机译： CALAMUS ORNATUS 的天然来源组合物，用于抗炎应用

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摘要

This invention pertains to derivatives of Calamus ornatus extracts and pure compound derivatives consistent with spirostanol saponins as selective inhibitors of cyclooxygenase 2 (COX-2). Activation of COX-2 is implicated with intense inflammation and pain, as well as other biological processes such as oncogenesis, angiogenesis and even for bowel movement. Hence, such activity of the compositions against COX-2 makes it a promising anti-inflammatory agent. With its different structure from the traditional COX-2 inhibitors, as well as the use of the source plant as a traditional food source, it is also likely that the invention might be safer to use, acutely or chronically. 展开▼

机译：本发明涉及Cal蒲提取物的衍生物和与作为环氧化酶2（COX-2）的选择性抑制剂的螺固醇皂苷一致的纯化合物衍生物。 COX-2的激活与强烈的炎症和疼痛以及其他生物过程（如肿瘤发生，血管生成，甚至排便）有关。因此，组合物对COX-2的这种活性使其成为有希望的抗炎剂。由于其结构不同于传统的COX-2抑制剂，并且使用来源植物作为传统的食物来源，因此本发明在急性或长期使用方面也可能更安全。展开▼

著录项

公开/公告号WO2016153365A1

专利类型

公开/公告日2016-09-29

原文格式PDF

申请/专利权人 YU GRACIA FE;
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申请/专利号WO2016PH50002

发明设计人 CRUZ LOURDES;
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申请日2016-03-23

分类号A61K36/38;A61K36/882;A61P29;

国家 WO

入库时间 2022-08-21 14:16:33

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