首页>
外国专利>
SUCCINIMIDE ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS
SUCCINIMIDE ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS
展开▼
机译:氨基亚磺酰胺活化的硝基化合物及其用于蛋白质硝基氧化的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to succinimide activated nitroxyl compounds and methods for the synthesis of such compounds. Th e present invention also relates to the use of succinimide activated nitroxyl compounds to prepare nitroxylated proteins for example nitroxylated heme proteins (e.g. nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO) for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins a nd methods for the use of nitroxylated proteins in the treatment of various conditions.
展开▼