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COMBINATION OF MORPHINANFORBINDELSER AND antidepressants in treating pseudobulbar affect

机译：吗啡释放抑制剂和抗抑郁药的组合治疗假性鳞茎疾病

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摘要

Provided herein are compositions comprising a dextromethorphan analog according to Formula I or Formula II or a pharmaceutically acceptable salt thereof of either of the foregoing, and a co-agent, e.g. , an antidepressant such as a serotonin norepinephrine reuptake inhibitor; a serotonin noradrenaline dopamine reuptake inhibitor; a norepinephrine dopamine reuptake inhibitor; a monoamine oxidase inhibitor; a selective serotonin reuptake inhibitor; and a tricyclic antidepressant or a pharmaceutically acceptable salt of any of the foregoing. The compositions are useful in the treatment of pseudobulbar affect, neuropathic pain, neurodegenerative diseases, brain injuries, and the like.

机译：本文提供了组合物，其包含根据式I或式II的右美沙芬类似物或其前述任一项的药学上可接受的盐，以及助剂，例如药学上可接受的。，一种抗抑郁药，例如5-羟色胺去甲肾上腺素再摄取抑制剂; 5-羟色胺去甲肾上腺素多巴胺再摄取抑制剂;去甲肾上腺素多巴胺再摄取抑制剂;单胺氧化酶抑制剂;选择性5-羟色胺再摄取抑制剂;以及任何前述的三环抗抑郁药或药学上可接受的盐。该组合物可用于治疗假性鳞茎疾病，神经性疼痛，神经退行性疾病，脑损伤等。

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公开/公告号DK2397158T3

专利类型
公开/公告日2016-07-25

原文格式PDF
申请/专利权人 CONCERT PHARMACEUTICALS INC.;
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申请/专利号DK20110180603T
发明设计人 THOMAS AMANDA;
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申请日2009-10-30
分类号A61K45/06;A61K31/135;A61K31/137;A61K31/138;A61K31/15;A61K31/343;A61K31/4525;A61K31/485;A61P25;
国家 DK
入库时间 2022-08-21 14:26:23

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