首页> 外国专利> method for processing an individual's genomic data, use of genomic sequence information, optionally in combination with gene expression information, clinical decision support and storage system and system

method for processing an individual's genomic data, use of genomic sequence information, optionally in combination with gene expression information, clinical decision support and storage system and system

机译:处理个人基因组数据的方法,基因组序列信息的使用,以及与基因表达信息的组合,临床决策支持和存储系统以及系统

摘要

Method for processing an individual's genomic data, Use of genomic sequence information, optionally in combination with gene expression information, Support to the present invention relates to a method for processing an individual's genomic data comprising (a) obtaining a genomic sequence of the individual; (b) reduce the complexity and / or amount of genomic sequence information; and (c) storing the genomic sequence information from step (b) in a readily retrievable form. The present invention also relates to a method wherein the step of reducing the complexity and / or amount of genomic sequence information is performed by cutting said genomic sequence information except for signature data pertaining to a disease or disorder, or aligning a genomic sequence of the subject with a reference sequence comprising signature data pertaining to a disease or disorder. furthermore, the invention relates to a method wherein the use of an individual's functional genetic information, in particular gene expression data is including, as well as a method, wherein the information is matrix encoded and decoded and represents based on markov chain processes. The information obtained may also be used to diagnose, detect, monitor or predict a disease and / or to prepare a molecular history of the individual. In addition, a corresponding clinical decision support and storage system is provided, preferably in the form of an electronic image / data archiving and communication system.
机译:用于处理个体基因组数据的方法,基因组序列信息的使用,可选地与基因表达信息结合使用。本发明的支持涉及一种用于处理个体基因组数据的方法,该方法包括:(a)获得个体的基因组序列; (b)降低基因组序列信息的复杂性和/或数量; (c)以易于检索的形式存储来自步骤(b)的基因组序列信息。本发明还涉及一种方法,其中降低基因组序列信息的复杂性和/或数量的步骤是通过切割除与疾病或病症有关的特征数据之外的所述基因组序列信息,或比对受试者的基因组序列来进行的。参考序列包括与疾病或病症有关的签名数据。此外,本发明涉及一种方法,其中包括使用个体的功能遗传信息,特别是基因表达数据,以及一种方法,其中该信息被矩阵编码和解码并且基于马尔可夫链过程表示。获得的信息还可用于诊断,检测,监测或预测疾病和/或准备个体的分子史。另外,提供了相应的临床决策支持和存储系统,优选地以电子图像/数据归档和通信系统的形式。

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