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Family of aryl, heteroaryl, O-aryl and O-heteroaryl carbasugars

机译：芳基，杂芳基，O-芳基和O-杂芳基碳糖

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摘要

The present invention relates to a compound of the following formula (I): as well as its process of preparation, pharmaceutical and cosmetics composition comprising it and use thereof, notably as an inhibitor of the sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, in particular in the treatment or prevention of diabetes, and more particularly type-II diabetes, diabetes-related complications, such as arthritis of the lower extremities, cardiac infarction, renal insufficiency, neuropathy or blindness, hyperglycemia, hyperinsulinemia, obesity, hypertriglyceridemia, X syndrome and arteriosclerosis, as well as for its use as an anticancer, anti-infective, anti-viral, anti-thrombotic or anti-inflammatory drug, or for lightening, bleaching, depigmenting the skin, removing blemishes from the skin, particularly age spots and freckles, or preventing pigmentation of the skin.; embedded image

机译：本发明涉及下式（I）的化合物：及其制备方法，包含该化合物的药物和化妆品组合物及其用途，特别是作为钠依赖性葡萄糖共转运蛋白如SGLT1的抑制剂。 SGLT2和SGLT3，尤其是在糖尿病的治疗或预防中，尤其是在II型糖尿病中，与糖尿病有关的并发症，例如下肢关节炎，心梗，肾功能不全，神经病变或失明，高血糖症，高胰岛素血症，肥胖，高甘油三酸酯血症，X综合征和动脉硬化，以及用作抗癌，抗感染，抗病毒，抗血栓形成或抗炎药，或用于美白，漂白，去色素，去除皮肤上的斑点皮肤，尤其是老年斑和雀斑，或防止皮肤色素沉着。 “嵌入式图像”

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公开/公告号US9434670B2

专利类型
公开/公告日2016-09-06

原文格式PDF
申请/专利权人 GERALDINE DELIENCOURT-GODEFROY;LENAIG LOPES;
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申请/专利号US201214119265
发明设计人 GERALDINE DELIENCOURT-GODEFROY;LENAIG LOPES;
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申请日2012-05-29
分类号C07C43/29;A61K31/085;C07C43/225;C07C43/23;C07C43/247;C07C43/253;C07D231/20;C07D333/16;A61K8/34;A61K8/49;A61Q19/02;C07C41/09;C07C41/22;C07C41/24;
国家 US
入库时间 2022-08-21 14:29:06

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