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RbAp48 transgenic mice for drug discovery in age-related memory decline
RbAp48 transgenic mice for drug discovery in age-related memory decline
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机译：RbAp48转基因小鼠用于发现与年龄有关的记忆衰退的药物
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摘要
Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase IIa promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject.
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