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Novel Suicidal LSD1 Inhibitors Targeting SOX2-Expressing Cancer Cells

机译：新型自杀性LSD1抑制剂靶向表达SOX2的癌细胞。

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摘要

Disclosed are inhibitors of lysine-specific demethylase I (LSD1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating cancers characterized by the presence of Sox2 using the compounds and compositions Also disclosed are methods of treating cancers characterized by the presence of Sox2 using inhibitors of LSD1 and/or histone deacetylation I (HDAC1). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

机译：公开了赖氨酸特异性脱甲基酶I（LSD1）的抑制剂。化合物的合成方法;包含化合物的药物组合物;用化合物和组合物治疗以Sox2为特征的癌症的方法和方法还公开了使用LSD1和/或组蛋白脱乙酰基I（HDAC1）抑制剂治疗以Sox2为特征的癌症的方法。该摘要旨在用作特定领域中进行搜索的扫描工具，而并非旨在限制本发明。

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公开/公告号US2016120862A1

专利类型
公开/公告日2016-05-05

原文格式PDF
申请/专利权人 THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BE HALF OF THE UNIVERSITY OF N;
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申请/专利号US201414894893
发明设计人 HUI ZHANG;
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申请日2014-05-30
分类号A61K31/495;A61K31/325;A61K31/40;A61K31/185;A61K31/135;C07C271/24;A61K31/4406;
国家 US
入库时间 2022-08-21 14:35:17

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